Genetically engineering glycolysis in T cells increases their antitumor functionRaphaëlle Toledano Zur, Orna Atar, Tilda Barliya, Shiran Hoogi, Ifat Abramovich, Eyal Gottlieb, Noga Ron-Harel, Cyrille J Cohen
4 July 2024
Tethered IL15-IL15Rα augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse modelInés Sánchez-Moreno, Aritz Lasarte-Cia, Celia Martín-Otal, Noelia Casares, Flor Navarro, Marta Gorraiz, Patricia Sarrión, Sandra Hervas-Stubbs, Lorea Jordana, Juan Roberto Rodriguez-Madoz, Jesús San Miguel, Felipe Prosper, Juan Jose Lasarte, Teresa Lozano
1 July 2024
Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphomaSushma Bharadwaj, Eric Lau, Mark P Hamilton, Anmol Goyal, Hrishi Srinagesh, Alexandria Jensen, Dasom Lee, Jayasindhu Mallampet, Sarah Elkordy, Shriya Syal, Sunita Patil, Theresa Latchford, Bita Sahaf, Sally Arai, Laura J JohnstonSee the full list of authors
1 July 2024
Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cellsMegen C Wittling, Hannah M Knochelmann, Megan M Wyatt, Guillermo O Rangel Rivera, Anna C Cole, Gregory B Lesinski, Chrystal M Paulos
30 June 2024
EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretionYuanyuan Chen, Dijun Ouyang, Yan Wang, Qiuzhong Pan, Jingjing Zhao, Hao Chen, Xinyi Yang, Yan Tang, Qijing Wang, Yongqiang Li, Jia He, Jin-Qi You, Yingzi Li, Chi Xu, Yan RenSee the full list of authors
17 June 2024
An innovative single-cell approach for phenotyping and functional genotyping of CAR NK cellsMatthew Ryan Sullivan, Michael Finocchiaro, Yichao Yang, Judene Thomas, Alaa Ali, Isabel Kaplan, Yasmin Abdulhamid, Eden Bobilev, Michal Sheffer, Rizwan Romee, Tania Konry
31 May 2024
Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypesNoam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Zhiya Yu, Sivasish Sindiri, Jared J Gartner, Maria Parkhurst, Sri Krishna, Frank J Lowery, Nikolaos Zacharakis, Lior Levy, Todd D Prickett, Tiffany Benzine, Satyajit RaySee the full list of authors
30 May 2024
Real-world experience of commercial relmacabtagene autoleucel (relma-cel) for relapsed/refractory central nervous system lymphoma: a multicenter retrospective analysis of patients in ChinaWenyan Yu, Liang Huang, Heng Mei, Yuhua Li, Ting Niu, Dehui Zou, Yao Liu, Huilai Zhang, Peng Liu, Jianqiu Wu, Zhi Wang, Hui Li, Qingqing Cai, Jian-qing Mi
27 May 2024
Developing a membrane-proximal CD33-targeting CAR T cellRuby Freeman, Sanam Shahid, Abdul G Khan, Serena C Mathew, Sydney Souness, Erin R Burns, Jasmine S Um, Kento Tanaka, Winson Cai, Sarah Yoo, Andrew Dunbar, Young Park, Devin McAvoy, Kinga K Hosszu, Ross L LevineSee the full list of authors
20 May 2024
Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid cancersTessa Gargett, Nga T H Truong, Bryan Gardam, Wenbo Yu, Lisa M Ebert, Amy Johnson, Erica C F Yeo, Nicole L Wittwer, Gonzalo Tapia Rico, Jesikah Logan, Purany Sivaloganathan, Maria Collis, Andrew Ruszkiewicz, Michael P Brown
15 May 2024