Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapyWen Luo, Hai Hoang, Hongwen Zhu, Katherine Miller, Xiaokui Mo, Shiori Eguchi, Meijuan Tian, Yanling Liao, Janet Ayello, Jeremy M Rosenblum, Mario Marcondes, Mark Currier, Elaine Mardis, Timothy Cripe, Dean LeeSee the full list of authors
12 September 2024
Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirusStefan Barisic, Elizabeth M Brahmbhatt, Elena Cherkasova, Timothy T Spear, Ujjawal Savani, Stephanie Pierre, Gina M Scurti, Long Chen, Muna Igboko, Rosa Nadal, Gang Zeng, Gordon Parry, David F Stroncek, Steven Highfill, Annika V DalheimSee the full list of authors
11 September 2024
Identification of Siglec-10 as a new dendritic cell checkpoint for cervical cancer immunotherapyCongwen Wang, Lewei He, Jing Peng, Chong Lu, Meng Zhang, Xingling Qi, Mingxing Zhang, Yumeng Wang
28 August 2024
NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumorsKensuke Nakagawara, Makoto Ando, Tanakorn Srirat, Setsuko Mise-Omata, Taeko Hayakawa, Minako Ito, Koichi Fukunaga, Akihiko Yoshimura
16 August 2024
EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responsesLeesa Lertsumitkul, Melinda Iliopoulos, Stacie S Wang, Sarah J McArthur, Lisa M Ebert, Alexander J Davenport, Raelene Endersby, Jordan R Hansford, Katharine J Drummond, Ryan Cross, Misty R Jenkins
7 August 2024
EphA3 CAR T cells are effective against glioblastoma in preclinical modelsPaulo Martins, Rochelle C J D’Souza, Niclas Skarne, Lea Lekieffre, Shane Horsefield, Madusha Ranjankumar, Xiang Li, Thuy T Le, Fiona Smith, Corey Smith, Jacqueline Burrows, Bryan W Day, Rajiv Khanna
7 August 2024
Preclinical activity of allogeneic SLAMF7-specific CAR T-cells (UCARTCS1) in multiple myelomaCharlotte L B M Korst, Chloe O’Neill, Wassilis S C Bruins, Meliha Cosovic, Inoka Twickler, Christie P M Verkleij, Diane Le Clerre, Maria Themeli, Isabelle Chion-Sotinel, Sonja Zweegman, Roman Galetto, Tuna Mutis, Niels W C J van de Donk
25 July 2024
Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapyHaider Al-janabi, Katy Moyes, Richard Allen, Matthew Fisher, Mateus Crespo, Bora Gurel, Pasquale Rescigno, Johann de Bono, Harry Nunns, Christopher Bailey, Anna Junker-Jensen, Munitta Muthana, Wayne A Phillips, Helen B Pearson, Mary-Ellen TaplinSee the full list of authors
25 July 2024
Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cellsAnders W Matson, Rob Hullsiek, Kate J Dixon, Sam Wang, Anders J Lindstedt, Ryan R Friess, Shee Kwan Phung, Tanya S Freedman, Martin Felices, Emily N Truckenbrod, Jianming Wu, Jeffrey S Miller, Bruce Walcheck
24 July 2024
rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumorsDan Li, Tianyuzhou Liang, Laura E Hutchins, Alexandra A Wolfarth, Sara Ferrando-Martinez, Byung Ha Lee, Mitchell Ho
23 July 2024