Clinical/Translational Cancer Immunotherapy

Section Edited by Douglas G. McNeel, MD, PhD; Claudia Palena, PhD; and Jeffrey S. Weber, MD, PhD First-in-man clinical trials (prospective clinical data only); phase II/III clinical studies; immune monitoring investigations;.

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TitleAuthorDate

Reconstruction of unreported subgroup survival data with PD-L1-low expression in advanced/metastatic triple-negative breast cancer using innovative KMSubtraction workflow

Yan Li, Xueyan Liang, Huijuan Li, Xiaoyu Chen

11 January 2024

Short-course neoadjuvant radiotherapy combined with chemotherapy and toripalimab for locally advanced esophageal squamous cell carcinoma (SCALE-1): a single-arm phase Ib clinical trial

Ning Jiang, Jingyuan Zhang, Zhen Guo, Yinan Wu, Lijun Zhao, Cheng Kong, Xue Song, Lingling Gu, Yang Zhao, Si Li, Xia He, Binhui Ren, Xiangzhi Zhu, Ming Jiang

9 January 2024

Cell membrane-anchored and tumor-targeted IL-12 T-cell therapy destroys cancer-associated fibroblasts and disrupts extracellular matrix in heterogenous osteosarcoma xenograft models

Jiemiao Hu, Alexander J Lazar, Davis Ingram, Wei-Lien Wang, Wendong Zhang, Zhiliang Jia, Dristhi Ragoonanan, Jian Wang, Xueqing Xia, Kris Mahadeo, Richard Gorlick, Shulin Li

9 January 2024

Clearing soluble MIC reverses the impaired function of natural killer cells from patients with multiple myeloma

Sojeong Kim, Haerim Chung, Jeong-Eun Kwak, Yu Ri Kim, Chung Hyun Park, Yeonhee Kim, June-Won Cheong, Jennifer Wu, Eui-Cheol Shin, Hyunsoo Cho, Jin Seok Kim

8 January 2024

mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer

No-Joon Song, Karthik B Chakravarthy, Hyeongseon Jeon, Chelsea Bolyard, Kelsi Reynolds, Kevin P Weller, Sarah Reisinger, Yi Wang, Anqi Li, Sizun Jiang, Qin Ma, Dan H Barouch, Mark P Rubinstein, Peter G Shields, Eugene M OltzSee the full list of authors

4 January 2024

Phase 2 trial of a DNA vaccine (pTVG-HP) and nivolumab in patients with castration-sensitive non-metastatic (M0) prostate cancer

Douglas G McNeel, Hamid Emamekhoo, Jens C Eickhoff, Christos E Kyriakopoulos, Ellen Wargowski, Tommaso P Tonelli, Laura E Johnson, Glenn Liu

14 December 2023

Intravesical Ty21a treatment of non-muscle invasive bladder cancer induces immune responses that correlate with safety and may be associated to therapy potential

Laurent Derré, Ilaria Lucca, Valérie Cesson, Perrine Bohner, Francois Crettenand, Sonia-Cristina Rodrigues-Dias, Florence Dartiguenave, Audrey Masnada, Carla Teixeira-Pereira, Sulayman Benmerzoug, Mathieu F Chevalier, Sonia Domingos-Pereira, Sylvain Nguyen, Lenka Polak, Anna K SchneiderSee the full list of authors

14 December 2023

First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial

Alex De Caluwe, Emanuela Romano, Philip Poortmans, Andrea Gombos, Elisa Agostinetto, Guilherme Nader Marta, Zoe Denis, Stylianos Drisis, Christophe Vandekerkhove, Antoine Desmet, Catherine Philippson, Ligia Craciun, Isabelle Veys, Denis Larsimont, Marianne PaesmansSee the full list of authors

6 December 2023

Differential requirements for CD4+ T cells in the efficacy of the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain metastasis models

Manali S Phadke, Jiannong Li, Zhihua Chen, Paulo C Rodriguez, Jessica K Mandula, Lilit Karapetyan, Peter A Forsyth, Y Ann Chen, Keiran S M Smalley

6 December 2023

Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma

Matthew H G Katz, Gina R Petroni, Todd Bauer, Matthew J Reilley, Brian M Wolpin, Chee-Chee Stucky, Tanios S Bekaii-Saab, Rawad Elias, Nipun Merchant, Andressa Dias Costa, Patrick Lenehan, Victoire Cardot-Ruffino, Scott Rodig, Kathleen Pfaff, Stephanie K DouganSee the full list of authors

1 December 2023

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