Basic Tumor Immunology

Section Edited by Cornelis J.M. Melief, MD, PhD and Sjoerd H. van der Burg, PhD Tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response, cancer and inflammation, preclinical models, chemotherapy and radiotherapy interactions/combinations of chemotherapy and radiotherapy, other combination treatments with the anti-tumor immune response, and oncolytic viruses.

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TitleAuthorDate

Comparative analysis of immune infiltrates in head and neck cancers across anatomical sites

Tara Muijlwijk, Dennis N L M Nijenhuis, Sonja H Ganzevles, Arjen Brink, Changlin Ke, Joseph N Fass, Venkatesh Rajamanickam, C René Leemans, Yoshinobu Koguchi, Bernard A Fox, Jos B Poell, Ruud H Brakenhoff, Rieneke van de Ven

11 January 2024

ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3

Yong-Qiang Ao, Jian Gao, Chun Jin, Shuai Wang, Li-Cheng Zhang, Jie Deng, Zong-wei Chen, Hai-Kun Wang, Jia-Hao Jiang, Jian-Yong Ding

26 December 2023

M1 macrophages induce PD-L1 cell-led collective invasion in HPV-positive head and neck squamous cell carcinoma via TNF-α/CDK4/UPS14

Jiashun Wu, Xin Pang, Xiao Yang, Mei Zhang, Bingjun Chen, Huayang Fan, Haofan Wang, Xianghua Yu, Yaling Tang, Xinhua Liang

26 December 2023

Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a-based and Siglece-based vaccination induces antitumor immunity and inhibits metastasis

Jason A Carter, Bharati Matta, Jenna Battaglia, Carter Somerville, Benjamin D Harris, Margaret LaPan, Gurinder S Atwal, Betsy J Barnes

22 December 2023

Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis

Yuru Chen, Jiazheng Sun, Jiazhou Liu, Yuxian Wei, Xiaoyu Wang, Huiying Fang, Huimin Du, Jing Huang, Qin Li, Guosheng Ren, Xiaoyi Wang, Hongzhong Li

7 December 2023

Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells

Lei Wu, Xudong Liu, Juan Lei, Nan Zhang, Huakan Zhao, Jiangang Zhang, Huan Deng, Yongsheng Li

6 December 2023

Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity

Jingyang Li, Xiaoyu Han, Mayu Sun, Weida Li, Guanghuan Yang, Huiyi Chen, Bao Guo, Jingquan Li, Xiaoguang Li, Hui Wang

6 December 2023

Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway

Xufen Zheng, Yuxiang Luo, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona JiaSee the full list of authors

6 December 2023

Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions

Roeland Lameris, Adam Shahine, Myrthe Veth, Bart Westerman, Dale I Godfrey, David Lutje Hulsik, Patricia Brouwer, Jamie Rossjohn, Tanja D de Gruijl, Hans J van der Vliet

1 December 2023

Delayed vaccine-induced CD8 T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication

Tetje C van der Sluis, Floortje J van Haften, Suzanne van Duikeren, Iris N Pardieck, J Fréderique de Graaf, Ward Vleeshouwers, Koen van der Maaden, Cornelis J M Melief, Sjoerd H van der Burg, Ramon Arens

29 November 2023

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